Scar conducting channel characterization to predict arrhythmogenicity during ventricular tachycardia ablation.
Europace
; 25(3): 989-999, 2023 03 30.
Article
en En
| MEDLINE
| ID: mdl-36607130
ABSTRACT
AIMS:
Heterogeneous tissue channels (HTCs) detected by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) are related to ventricular arrhythmias, but there are few published data about their arrhythmogenic characteristics. METHODS ANDRESULTS:
We enrolled 34 consecutive patients with ischaemic and non-ischaemic cardiomyopathy who were referred for ventricular tachycardia (VT) ablation. LGE-CMR was performed prior to ablation, and the HTCs were analyzed. Arrhythmogenic HTCs linked to induced VT were identified during the VT ablation procedure. The characteristics of arrhythmogenic HTCs were compared with those of non-arrhythmogenic HTCs. Three patients were excluded due to low-quality LGE-CMR images. A total of 87 HTCs were identified on LGE-CMR in 31 patients (age63.8 ± 12.3 years; 96.8% male; left ventricular ejection fraction 36.1 ± 10.7%). Of the 87 HTCs, only 31 were considered arrhythmogenic because of their relation to a VT isthmus. The HTCs related to a VT isthmus were longer [64.6 ± 49.4 vs. 32.9 ± 26.6 mm; OR 1.02; 95% CI (1.01-1.04); P < 0.001] and had greater mass [2.5 ± 2.2 vs. 1.2 ± 1.2 grams; OR 1.62; 95% CI (1.18-2.21); P < 0.001], a higher degree of protectedness [26.19 ± 19.2 vs. 10.74 ± 8.4; OR 1.09; 95% CI (1.04-1.14); P < 0.001], higher transmurality [number of wall layers with CCs 3.8 ± 2.4 vs. 2.4 ± 2.0; OR 1.31; 95% CI (1.07-1.60); P = 0.008] and more ramifications [3.8 ± 2.0 vs. 2.7 ± 1.1; OR 1.59; 95% CI (1.15-2.19); P = 0.002] than non-arrhythmogenic HTCs. Multivariate logistic regression analysis revealed that protectedness was the strongest predictor of arrhythmogenicity.CONCLUSION:
The protectedness of an HTC identified by LGE-CMR is strongly related to its arrhythmogenicity during VT ablation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Taquicardia Ventricular
/
Ablación por Catéter
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Año:
2023
Tipo del documento:
Article