Fluorescence lifetime distribution in phakic and pseudophakic healthy eyes.
PLoS One
; 18(1): e0279158, 2023.
Article
en En
| MEDLINE
| ID: mdl-36608033
ABSTRACT
PURPOSE:
To investigate the influence of the lens status and to describe fundus autofluorescence lifetimes (FLT) in a large cohort of healthy eyes across a wide age range. MATERIALS ANDMETHODS:
FLT data were acquired from healthy phakic and pseudophakic eyes using fluorescence lifetime imaging ophthalmoscopy (FLIO). Retinal autofluorescence was excited with a 473 nm laser and emitted autofluorescence was detected in a short and a long spectral channel (SSC 498-560 nm; LSC 560-720 nm).RESULTS:
141 healthy eyes from 141 participants (56 ± 18 years) were included. The shortest mean FLTs were measured within the macular center, followed by the temporal inner and outer ETDRS (Early Treatment Diabetic Retinopathy Study) grid segments, and the remaining areas of the inner and the outer ETDRS ring. In phakic participants (81%), mean, short and long FLTs correlated with the age (SSC r2 = 0.54; LSC r2 = 0.7; both p<0.0001) with an increase of about 33 ps in the SSC resp. 28 ps in the LSC per decade. In pseudophakic subjects (19%), mean FLTs only correlated with age in the long spectral channel (r2 = 0.44; p = 0.0002) but not in the short spectral channel (r2 = 0.066; p = 0.2).CONCLUSIONS:
Fundus autofluorescence lifetimes are age dependent. FLTs in the SSC are more susceptible to lens opacities but less dependent on age changes, whereas FLTs in the LSC are largely independent of the lens status but display a higher degree of age dependency. STUDY REGISTRY ClinicalTrials.gov NCT01981148.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retina
/
Imagen Óptica
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article