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EFMC: Trends in Medicinal Chemistry and Chemical Biology.
Auberson, Yves P; Arimondo, Paola B; Duca, Maria; Essig, Sebastian; Grether, Uwe; Rufer, Arne C; Sbardella, Gianluca; Schopfer, Ulrich; Torrens, Antoni; van der Stelt, Mario; Vauzeilles, Boris; Vázquez, Olalla; Zhang, Andrew X.
Afiliación
  • Auberson YP; Global Discovery Chemistry, Novartis Institutes for BioMedical Research Novartis Campus - WSJ-88.10, 4056, Basel, Switzerland.
  • Arimondo PB; Department Epigenetic Chemical Biology, Institut Pasteur, Université de Paris CNRS UMR3523 Chem4Life, 28 rue du Dr Roux, 75015, Paris, France.
  • Duca M; Université Côte d'Azur Institut de Chimie de Nice (ICN), UMR7272 CNRS Parc Valrose, 06100, Nice, France.
  • Essig S; Bayer AG, Research & Development, Pharmaceuticals, Drug Discovery Sciences, Life Science Technologies Aprather Weg 18a, Gebäude 460, Raum 345, 42113, Wuppertal, Germany.
  • Grether U; F. Hoffmann-La Roche Ltd. Pharma Research and Early Development, pRED, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Rufer AC; F. Hoffmann-La Roche Ltd. Pharma Research and Early Development, pRED, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Sbardella G; Epigenetic Med Chem Lab, Department of Pharmacy, University of Salerno via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy.
  • Schopfer U; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research Novartis Campus - WSJ-182.Z4.249.14, 4056, Basel, Switzerland.
  • Torrens A; ABAC Therapeutics S.L. Joan XXIII, 10, 08950 Esplugues de Llobregat, Barcelona, Spain.
  • van der Stelt M; University of Leiden, Institute of Chemistry/Chemical Biology Gorlaeus Building, room DE3.19, Einsteinweg 55, 2333, CC Leiden, The Netherlands.
  • Vauzeilles B; Chemical Biology Department, Université Paris-Saclay, CNRS Institut de Chimie des Substances Naturelles UPR 2301, 91198, Gif-sur-Yvette, France.
  • Vázquez O; Philipps-Universität Marburg, Department of Chemistry & Center for Synthetic Microbiology (SYNMIKRO), D-35032, Marburg, Germany.
  • Zhang AX; Discovery Sciences, R&D, AstraZeneca, Waltham, MA 02451, USA.
Chembiochem ; 24(7): e202200690, 2023 04 03.
Article en En | MEDLINE | ID: mdl-36704975
ABSTRACT
Ground-breaking research in disease biology and continuous efforts in method development have uncovered a range of potential new drug targets. Increasingly, the drug discovery process is informed by technologies involving chemical probes as tools. Applications for chemical probes comprise target identification and assessment, as well as the qualification of small molecules as chemical starting points and drug candidates. Progress in probe chemistry has opened the way to novel assay formats and pharmaceutical compound classes. The European Federation of Medicinal Chemistry and Chemical Biology (EFMC) has launched the Chemical Biology Initiative to advance science in the field of medicinal chemistry and chemical biology, while representing all members of this extended scientific community. This review provides an overview of the many important developments in the field of chemical biology that have happened at the lively interface of academic and industrial research.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Química Farmacéutica / Descubrimiento de Drogas Idioma: En Año: 2023 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Química Farmacéutica / Descubrimiento de Drogas Idioma: En Año: 2023 Tipo del documento: Article