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Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals.
Phipps, Michael D; Cingoranelli, Shelbie; Bhupathiraju, N V S Dinesh K; Younes, Ali; Cao, Minhua; Sanders, Vanessa A; Neary, Michelle C; Devany, Matthew H; Cutler, Cathy S; Lopez, Gustavo E; Saini, Shefali; Parker, Candace C; Fernandez, Solana R; Lewis, Jason S; Lapi, Suzanne E; Francesconi, Lynn C; Deri, Melissa A.
Afiliación
  • Phipps MD; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States.
  • Cingoranelli S; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Bhupathiraju NVSDK; Department of Chemistry, Lehman College of the City University of New York, Bronx, New York10468, United States.
  • Younes A; Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York10065, United States.
  • Cao M; Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States.
  • Sanders VA; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Neary MC; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Devany MH; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Cutler CS; Medical Isotope Research and Production Laboratory, Collider-Accelerator Division, Brookhaven National Laboratory (BNL), Upton, New York11973, United States.
  • Lopez GE; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Saini S; Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States.
  • Parker CC; Medical Isotope Research and Production Laboratory, Collider-Accelerator Division, Brookhaven National Laboratory (BNL), Upton, New York11973, United States.
  • Fernandez SR; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States.
  • Lewis JS; Department of Chemistry, Lehman College of the City University of New York, Bronx, New York10468, United States.
  • Lapi SE; Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States.
  • Francesconi LC; Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States.
  • Deri MA; Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States.
Inorg Chem ; 62(50): 20567-20581, 2023 Dec 18.
Article en En | MEDLINE | ID: mdl-36724083
ABSTRACT
Three isotopes of scandium─43Sc, 44Sc, and 47Sc─have attracted increasing attention as potential candidates for use in imaging and therapy, respectively, as well as for possible theranostic use as an elementally matched pair. Here, we present the octadentate chelator 3,4,3-(LI-1,2-HOPO) (or HOPO), an effective chelator for hard cations, as a potential ligand for use in radioscandium constructs with simple radiolabeling under mild conditions. HOPO forms a 11 Sc-HOPO complex that was fully characterized, both experimentally and theoretically. [47Sc]Sc-HOPO exhibited good stability in chemical and biological challenges over 7 days. In healthy mice, [43,47Sc]Sc-HOPO cleared the body rapidly with no signs of demetalation. HOPO is a strong candidate for use in radioscandium-based radiopharmaceuticals.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Radiofármacos Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridonas / Radiofármacos Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article