[Effect of shikonin on proliferation, apoptosis, migration and angiogenesis of hemangioma endothelial cell].
Shanghai Kou Qiang Yi Xue
; 31(6): 576-580, 2022 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-36970791
ABSTRACT
PURPOSE:
To investigate the effect of shikonin (SKN) on proliferation, apoptosis, migration and angiogenesis of hemangioma endothelial cell (HemEC).METHODS:
CCK-8 and EdU assays were used to detect the effect of SKN on proliferation of HemEC. The effect of SKN on apoptosis of HemEC was detected by flow cytometry. Wound healing assay was used to detect the effect of SKN on migration ability of HemEC. The effect of SKN on angiogenesis ability of HemEC was detected by tube formation assay. SPSS 22.0 software package was used for statistical analysis of the data.RESULTS:
SKN inhibited proliferation (Pï¼0.001) and promoted apoptosis (Pï¼0.001) of HemEC in a concentration-dependent manner. In additon, SKN inhibited HemEC migration(Pï¼0.01) and angiogenesis(Pï¼0.001).CONCLUSIONS:
SKN can inhibit proliferation, migration, angiogenesis and promote apoptosis of HemEC.
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Banco de datos:
MEDLINE
Asunto principal:
Células Endoteliales
/
Hemangioma
Límite:
Humans
Idioma:
Zh
Año:
2022
Tipo del documento:
Article