A phase 3, randomised, double-blind, placebo-controlled clinical trial evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine in adults (ABDALA-3 study).

Hernández-Bernal, Francisco; Ricardo-Cobas, Maria C; Martín-Bauta, Yenima; Rodríguez-Martínez, Ernesto; Urrutia-Pérez, Klaudia; Urrutia-Pérez, Karen; Quintana-Guerra, Joel; Navarro-Rodríguez, Zadis; Piñera-Martínez, Marjoris; Rodríguez-Reinoso, José L; Chávez-Chong, Cristina O; Baladrón-Castrillo, Idania; Melo-Suárez, Grettel; Batista-Izquierdo, Alejandro; Pupo-Micó, Alexis; Mora-Betancourt, Ricardo; Bizet-Almeida, Jacqueline; Martínez-Rodríguez, Maria C; Lobaina-Lambert, Leonardo; Velázquez-Pérez, Vivian M; Soler-Díaz, Jalimy; Laurencio-Vallina, Sandra; Meriño-Hechavarría, Tamara; Carmenaty-Campos, Norberto; Rodríguez-Montero, Enri; Limonta-Fernández, Miladys; Alonso-Valdés, Marel; Hernández-Rodríguez, Reinier; Pimentel-Vázquez, Eulogio; Catasús-Álvarez, Karem M; Cabrera-Núñez, Maria V; Ayala-Ávila, Marta; Muzio-González, Verena L

Hernández-Bernal, Francisco; Ricardo-Cobas, Maria C; Martín-Bauta, Yenima; Rodríguez-Martínez, Ernesto; Urrutia-Pérez, Klaudia; Urrutia-Pérez, Karen; Quintana-Guerra, Joel; Navarro-Rodríguez, Zadis; Piñera-Martínez, Marjoris; Rodríguez-Reinoso, José L; Chávez-Chong, Cristina O; Baladrón-Castrillo, Idania; Melo-Suárez, Grettel; Batista-Izquierdo, Alejandro; Pupo-Micó, Alexis; Mora-Betancourt, Ricardo; Bizet-Almeida, Jacqueline; Martínez-Rodríguez, Maria C; Lobaina-Lambert, Leonardo; Velázquez-Pérez, Vivian M; Soler-Díaz, Jalimy; Laurencio-Vallina, Sandra; Meriño-Hechavarría, Tamara; Carmenaty-Campos, Norberto; Rodríguez-Montero, Enri; Limonta-Fernández, Miladys; Alonso-Valdés, Marel; Hernández-Rodríguez, Reinier; Pimentel-Vázquez, Eulogio; Catasús-Álvarez, Karem M; Cabrera-Núñez, Maria V; Ayala-Ávila, Marta; Muzio-González, Verena L.

Afiliación

Hernández-Bernal F; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Ricardo-Cobas MC; "Saturnino Lora" Provincial Hospital, Santiago de Cuba, Cuba.
Martín-Bauta Y; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Rodríguez-Martínez E; Cybernetics, Mathematics and Physics Institute, Havana, Cuba.
Urrutia-Pérez K; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Urrutia-Pérez K; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Quintana-Guerra J; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Navarro-Rodríguez Z; "Saturnino Lora" Provincial Hospital, Santiago de Cuba, Cuba.
Piñera-Martínez M; "Saturnino Lora" Provincial Hospital, Santiago de Cuba, Cuba.
Rodríguez-Reinoso JL; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Chávez-Chong CO; Cybernetics, Mathematics and Physics Institute, Havana, Cuba.
Baladrón-Castrillo I; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Melo-Suárez G; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Batista-Izquierdo A; "Lucía Iñiguez" Hospital, Holguín, Cuba.
Pupo-Micó A; "Lucía Iñiguez" Hospital, Holguín, Cuba.
Mora-Betancourt R; "Rubén Batista Rubio" Polyclinic, Holguín, Cuba.
Bizet-Almeida J; "Saturnino Lora" Provincial Hospital, Santiago de Cuba, Cuba.
Martínez-Rodríguez MC; "Asdrúbal López" Polyclinic, Guantánamo, Cuba.
Lobaina-Lambert L; "Saturnino Lora" Provincial Hospital, Santiago de Cuba, Cuba.
Velázquez-Pérez VM; "Armando García" Polyclinic, Santiago de Cuba, Cuba.
Soler-Díaz J; "Julian Grimau" Polyclinic, Santiago de Cuba, Cuba.
Laurencio-Vallina S; "Joaquín Castillo Duany" Hospital, Santiago de Cuba, Cuba.
Meriño-Hechavarría T; "Joaquín Castillo Duany" Hospital, Santiago de Cuba, Cuba.
Carmenaty-Campos N; "Joaquín Castillo Duany" Hospital, Santiago de Cuba, Cuba.
Rodríguez-Montero E; "Joaquín Castillo Duany" Hospital, Santiago de Cuba, Cuba.
Limonta-Fernández M; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Alonso-Valdés M; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Hernández-Rodríguez R; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Pimentel-Vázquez E; Biotechnological and Pharmaceutical Industries Group, BioCubaFarma, Havana, Cuba.
Catasús-Álvarez KM; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Cabrera-Núñez MV; Virology Laboratory of the Center for Hygiene, Epidemiology and Microbiology, Santiago de Cuba, Cuba.
Ayala-Ávila M; Genetic Engineering and Biotechnology Centre, Havana, Cuba.
Muzio-González VL; Genetic Engineering and Biotechnology Centre, Havana, Cuba.

Lancet Reg Health Am ; 21: 100497, 2023 May.

Article en En | MEDLINE | ID: mdl-37192953

Palabras clave

COVID-19; Controlled clinical trial; Double-blind; Efficacy; Phase 3; Placebo-controlled clinical trial; Randomised; SARS-CoV-2; Spike RBD protein; Vaccine

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