Population pharmacokinetics, pharmacodynamics and pharmacogenetics modelling of oxypurinol in Hmong adults with gout and/or hyperuricemia.

Wen, Ya-Feng; Brundage, Richard C; Roman, Youssef M; Culhane-Pera, Kathleen A; Straka, Robert J

Wen, Ya-Feng; Brundage, Richard C; Roman, Youssef M; Culhane-Pera, Kathleen A; Straka, Robert J.

Afiliación

Wen YF; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.
Brundage RC; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.
Roman YM; Department of Pharmacotherapy & Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.
Culhane-Pera KA; Minnesota Community Care, St. Paul, Minnesota, USA.
Straka RJ; Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.

Br J Clin Pharmacol ; 89(10): 2964-2976, 2023 10.

Article en En | MEDLINE | ID: mdl-37202871

Asunto(s)

Gota; Hiperuricemia; Transportadores de Anión Orgánico; Adulto; Humanos; Oxipurinol; Alopurinol/farmacocinética; Hiperuricemia/tratamiento farmacológico; Hiperuricemia/genética; Supresores de la Gota/farmacocinética; Farmacogenética; Gota/tratamiento farmacológico; Gota/genética; Transportadores de Anión Orgánico/uso terapéutico; Proteínas de Transporte de Catión Orgánico/genética

Palabras clave

NONMEM; allopurinol; gout; pharmacometrics; population pharmacokinetics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transportadores de Anión Orgánico / Hiperuricemia / Gota Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Año: 2023 Tipo del documento: Article

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