Identification of human urinary mitoxantrone metabolites.
Cancer Res
; 46(9): 4858-61, 1986 Sep.
Article
en En
| MEDLINE
| ID: mdl-3731132
ABSTRACT
Two polar metabolites of mitoxantrone, a clinically active antitumor agent, have been isolated and purified from the urine of patients by sequential absorption on glass wool and C18-Sep-Pak cartridges followed by preparative high-performance liquid chromatography. Negative ion chemical ionization mass spectrometry indicated that the two metabolites are the di- and mono-carboxylic acids resulting from oxidation of the terminal hydroxyl groups of the side chain(s). Mass spectral comparison of the urinary metabolites with synthetic compounds confirmed the identification.
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Banco de datos:
MEDLINE
Asunto principal:
Antraquinonas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Año:
1986
Tipo del documento:
Article