Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers.

Defour, Jean-Philippe; Leroy, Emilie; Dass, Sharmila; Balligand, Thomas; Levy, Gabriel; Brett, Ian C; Papadopoulos, Nicolas; Mouton, Céline; Genet, Lidvine; Pecquet, Christian; Staerk, Judith; Smith, Steven O; Constantinescu, Stefan N

Defour, Jean-Philippe; Leroy, Emilie; Dass, Sharmila; Balligand, Thomas; Levy, Gabriel; Brett, Ian C; Papadopoulos, Nicolas; Mouton, Céline; Genet, Lidvine; Pecquet, Christian; Staerk, Judith; Smith, Steven O; Constantinescu, Stefan N.

Afiliación

Defour JP; Ludwig Institute for Cancer Research, Brussels, Belgium.
Leroy E; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Dass S; Ludwig Institute for Cancer Research, Brussels, Belgium.
Balligand T; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Levy G; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, Newyork, United States.
Brett IC; Ludwig Institute for Cancer Research, Brussels, Belgium.
Papadopoulos N; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Mouton C; Ludwig Institute for Cancer Research, Brussels, Belgium.
Genet L; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
Pecquet C; WEL Research Institute, WELBIO Department, Wavre, Belgium.
Staerk J; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, Newyork, United States.
Smith SO; Ludwig Institute for Cancer Research, Brussels, Belgium.
Constantinescu SN; de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

Elife ; 122023 Jun 20.

Article en En | MEDLINE | ID: mdl-37338955

Asunto(s)

Receptores de Trombopoyetina; Transducción de Señal; Receptores de Trombopoyetina/genética; Receptores de Trombopoyetina/metabolismo; Línea Celular; Mutación; Estructura Secundaria de Proteína; Transducción de Señal/genética

Palabras clave

c-mpl ligand; cancer biology; cytokine receptor; helix dimerization; human; molecular biophysics; mouse; structural biology; thrombopoietin receptor; transmembrane domain

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Receptores de Trombopoyetina Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Receptores de Trombopoyetina Idioma: En Año: 2023 Tipo del documento: Article