Understanding fundamental principles of enhancer biology at a model locus: Analysing the structure and function of an enhancer cluster at the &#945;-globin locus.

Kassouf, Mira; Ford, Seren; Blayney, Joseph; Higgs, Doug

Understanding fundamental principles of enhancer biology at a model locus: Analysing the structure and function of an enhancer cluster at the α-globin locus.

Kassouf, Mira; Ford, Seren; Blayney, Joseph; Higgs, Doug.

Afiliación

Kassouf M; Laboratory of Gene Regulation, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ford S; Laboratory of Gene Regulation, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Blayney J; Laboratory of Gene Regulation, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Higgs D; Laboratory of Gene Regulation, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Bioessays ; 45(10): e2300047, 2023 10.

Article en En | MEDLINE | ID: mdl-37404089

Asunto(s)

Elementos de Facilitación Genéticos; Globinas alfa; Animales; Elementos de Facilitación Genéticos/genética; Globinas alfa/genética; Factores de Transcripción/metabolismo; Regiones Promotoras Genéticas/genética; Biología; Mamíferos/genética

Palabras clave

alpha globin locus; enhancer cluster; enhancer function; enhanceropathies; erythropoiesis; gene regulation; super-enhancer

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Elementos de Facilitación Genéticos / Globinas alfa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

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