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A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.
van der Krift, Felix; Zijlmans, Dick W; Shukla, Rhythm; Javed, Ali; Koukos, Panagiotis I; Schwarz, Laura LE; Timmermans-Sprang, Elpetra Pm; Maas, Peter Em; Gahtory, Digvijay; van den Nieuwboer, Maurits; Mol, Jan A; Strous, Ger J; Bonvin, Alexandre Mjj; van der Stelt, Mario; Veldhuizen, Edwin Ja; Weingarth, Markus; Vermeulen, Michiel; Klumperman, Judith; Maurice, Madelon M.
Afiliación
  • van der Krift F; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Zijlmans DW; Department of Molecular Biology and Oncode Institute, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Shukla R; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Javed A; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Koukos PI; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
  • Schwarz LL; Computational Structural Biology, Bijvoet Centre for Biomolecular Research, Faculty of Science, Department of Chemistry, Utrecht University, Utrecht, The Netherlands.
  • Timmermans-Sprang EP; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Maas PE; Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands.
  • Gahtory D; Specs Compound Handling B.V., Zoetermeer, The Netherlands.
  • van den Nieuwboer M; BIMINI Biotech B.V., Leiden, The Netherlands.
  • Mol JA; BIMINI Biotech B.V., Leiden, The Netherlands.
  • Strous GJ; Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands.
  • Bonvin AM; Center for Molecular Medicine, Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • van der Stelt M; Computational Structural Biology, Bijvoet Centre for Biomolecular Research, Faculty of Science, Department of Chemistry, Utrecht University, Utrecht, The Netherlands.
  • Veldhuizen EJ; Department of Molecular Physiology and Oncode Institute, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • Weingarth M; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
  • Vermeulen M; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
  • Klumperman J; Department of Molecular Biology and Oncode Institute, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Maurice MM; Center for Molecular Medicine, Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands.
Life Sci Alliance ; 6(11)2023 11.
Article en En | MEDLINE | ID: mdl-37591722

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antagonistas del Ácido Fólico Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antagonistas del Ácido Fólico Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article