Serotonergic multilocus genetic variation moderates the association between interpersonal relationship and adolescent depressive symptoms.
J Affect Disord
; 340: 616-625, 2023 11 01.
Article
en En
| MEDLINE
| ID: mdl-37597782
ABSTRACT
BACKGROUND:
Research suggests that genetic variants linked to serotonin functioning moderate the association between environmental stressors and depressive symptoms, but examining gene-environment interactions with single polymorphisms limits power.METHODS:
A multilocus genetic profile score (MGPS) approach to measuring serotonergic multilocus genetic variation and examined interactions with interpersonal relationship, insomnia with depressive symptoms as outcomes in an adolescent sample (average age = 14.15 ± 0.63 years since first measurement; range 13 to 15).RESULTS:
(1) interpersonal relationship predicted adolescent depressive symptoms; (2) insomnia mediated the effect of interpersonal relationships on adolescent depressive symptoms; (3) the THP2 gene rs4570625 polymorphism G allele was a key risk factor for depressive symptom, and the MGPS moderated the effects of teacher-student relationship and insomnia on adolescent depressive symptom. Specifically, as the MGPS increased, the effects of insomnia on adolescent depressive symptom were enhanced; further, when the MGPS score increased, the effect of teacher-student relationship on depression showed a similar phenomenon with an increased slope and enhanced prediction; and (4) the results of sensitivity analysis showed that multilocus genetic interaction with the environment had a better explanatory power and stability for depression than single polymorphism studies.CONCLUSION:
MGPS provides substantial power to examine gene-environmental interactions linked to affective outcomes among adolescents.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Depresión
/
Trastornos del Inicio y del Mantenimiento del Sueño
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article