Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway.

Pham, Thi Hoa; Lee, Gi Ho; Jin, Sun Woo; Lee, Seung Yeon; Han, Eun Hee; Kim, Nam Doo; Choi, Chul Yung; Jeong, Gil-Saeng; Ki Lee, Sang; Kim, Hyung Sik; Jeong, Hye Gwang

Pham, Thi Hoa; Lee, Gi Ho; Jin, Sun Woo; Lee, Seung Yeon; Han, Eun Hee; Kim, Nam Doo; Choi, Chul Yung; Jeong, Gil-Saeng; Ki Lee, Sang; Kim, Hyung Sik; Jeong, Hye Gwang.

Afiliación

Pham TH; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; Molecular Microbiology Lab, Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
Lee GH; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Jin SW; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Lee SY; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Han EH; Drug & Disease Target Research Team, Division of Bioconvergence Analysis, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea.
Kim ND; VORONOI BIO Inc., Incheon, Republic of Korea.
Choi CY; Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, Republic of Korea.
Jeong GS; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Ki Lee S; Department of Sport Science, College of Natural Science, Chungnam National University, Daejeon, Korea.
Kim HS; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address: hkims@skku.edu.
Jeong HG; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea. Electronic address: hgjeong@cnu.ac.kr.

Biochem Pharmacol ; 216: 115768, 2023 10.

Article en En | MEDLINE | ID: mdl-37652106

Asunto(s)

Lignanos; Enfermedad del Hígado Graso no Alcohólico; Humanos; Receptor alfa de Estrógeno/metabolismo; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Quinasa de la Proteína Quinasa Dependiente de Calcio-Calmodulina; Simulación del Acoplamiento Molecular; Hígado/metabolismo; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Lignanos/farmacología; Metabolismo de los Lípidos; Células Hep G2; Transducción de Señal; Palmitatos/metabolismo

Palabras clave

AMPK; ATGL; ERα; Lipid accumulation; SREBP-1c; Sesamin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Lignanos / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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