A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.

Hubert, Christopher G; Stauffer, Shaun R; Lathia, Justin D

Hubert, Christopher G; Stauffer, Shaun R; Lathia, Justin D.

Afiliación

Hubert CG; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America.
Stauffer SR; Case Comprehensive Cancer Center, Cleveland, Ohio, United States of America.
Lathia JD; Case Comprehensive Cancer Center, Cleveland, Ohio, United States of America.

PLoS Biol ; 21(9): e3002295, 2023 09.

Article en En | MEDLINE | ID: mdl-37713380

RESUMEN

Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.

Asunto(s)

Neoplasias del Colon; Resistencia a Antineoplásicos; Humanos; Resistencia a Antineoplásicos/genética; Epigénesis Genética; Neoplasias del Colon/tratamiento farmacológico; Neoplasias del Colon/genética; Células Madre Neoplásicas; Fenotipo; Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2; Proteínas de Neoplasias; Péptidos y Proteínas de Señalización Intracelular

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Colon / Resistencia a Antineoplásicos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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