Risk of genitourinary malignancy in patients that receive anticoagulant or antiplatelet therapy.
Bratisl Lek Listy
; 124(10): 738-741, 2023.
Article
en En
| MEDLINE
| ID: mdl-37789788
ABSTRACT
OBJECTIVES:
Haematuria is a common indication for a urology evaluation. In many cases, its cause is not determined unequivocally, but it does not pose any threat to the patient. However, it can represent the first symptom of urinary tract cancer.BACKGROUND:
The present study aimed to compare the risk of urological malignancies in patients with haematuria who received antiplatelet or anticoagulant therapy versus those who did not.METHODS:
This prospective study included 562 patients with haematuria during the period of 2018â2021. Among these, 129 patients had macroscopic haematuria. All patients underwent a urinary tract ultrasound, CT with urography, and cystoscopy. Patients with suspected malignancy underwent an appropriate surgical procedure with a pathology examination. Data were analysed with univariate and multiple logistic regression.RESULTS:
The incidence rates of malignancies were 21.5 % overall, and 44.2 % and 14.8 % among patients with macroscopic and microscopic haematuria, respectively. Univariate regression showed that the odds of malignancy was significantly higher among patients with antiplatelet therapy compared to patients without antiplatelet therapy (OR 1.88, 95% CI 1.14â3.05). In contrast, anticoagulation therapy did not significantly increase the odds of malignancy compared to no anticoagulation therapy (OR 1.45, 95% CI 0.74â2.69). However, a multiple logistic regression model that included other known risk factors (e.g., sex or age) showed similar odds of malignancy among these patient groups.CONCLUSIONS:
Malignancy risk for patients who received anticoagulant or antiplatelet therapy was similar to the risk observed in the general population. Antiplatelet and anticoagulant therapy were not significant risk factors of urological malignancy in patients with haematuria. The results from the present study will be used in a power analysis for an upcoming multicentre study (Tab. 4, Ref. 17). Text in PDF www.elis.sk Keywords anticoagulation therapy, antiplatelet therapy, cancer, haematuria, risk factor.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Urológicas
/
Hematuria
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article