Apolipoprotein C-III itself stimulates the Syk/cPLA2-induced inflammasome activation of macrophage to boost anti-tumor activity of CD8<sup>+</sup> T cell.

Hu, Xiangyu; Ding, Shizhen; Lu, Guotao; Lin, Zhijie; Liao, Liting; Xiao, Weiming; Ding, Yanbing; Zhang, Yu; Wang, Zhengbing; Gong, Weijuan; Jia, Xiaoqin

Apolipoprotein C-III itself stimulates the Syk/cPLA2-induced inflammasome activation of macrophage to boost anti-tumor activity of CD8⁺ T cell.

Hu, Xiangyu; Ding, Shizhen; Lu, Guotao; Lin, Zhijie; Liao, Liting; Xiao, Weiming; Ding, Yanbing; Zhang, Yu; Wang, Zhengbing; Gong, Weijuan; Jia, Xiaoqin.

Afiliación

Hu X; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Ding S; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Lu G; Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Lin Z; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Liao L; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Xiao W; Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Ding Y; Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Zhang Y; School of Nursing, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Wang Z; Jiangsu Key Laboratory of Zoonosis, Yangzhou, 225001, People's Republic of China.
Gong W; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Jia X; Department of Basic Medicine, School of Medicine, Yangzhou University, Yangzhou, 225001, People's Republic of China.

Cancer Immunol Immunother ; 72(12): 4123-4144, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37853273

Asunto(s)

Inflamasomas; Neoplasias; Ratones; Animales; Inflamasomas/metabolismo; Apolipoproteína C-III/metabolismo; Apolipoproteína C-III/farmacología; Linfocitos T CD8-positivos/metabolismo; Receptor Toll-Like 2/metabolismo; Macrófagos/metabolismo; Neoplasias/metabolismo; Fosfolipasas A2 Citosólicas/metabolismo; Fosfolipasas A2 Citosólicas/farmacología; Ratones Endogámicos C57BL

Palabras clave

Antitumor; ApoC3; CD8+ T; Inflammasome; Macrophage

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inflamasomas / Neoplasias Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inflamasomas / Neoplasias Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article