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Hierarchical assembly of tryptophan zipper peptides into stress-relaxing bioactive hydrogels.
Nguyen, Ashley K; Molley, Thomas G; Kardia, Egi; Ganda, Sylvia; Chakraborty, Sudip; Wong, Sharon L; Ruan, Juanfang; Yee, Bethany E; Mata, Jitendra; Vijayan, Abhishek; Kumar, Naresh; Tilley, Richard D; Waters, Shafagh A; Kilian, Kristopher A.
Afiliación
  • Nguyen AK; School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Molley TG; Australian Center for Nanomedicine, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Kardia E; School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Ganda S; Australian Center for Nanomedicine, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Chakraborty S; School of Materials Science and Engineering, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.
  • Wong SL; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Ruan J; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), University of New South Wales, Sydney, NSW, 2052, Australia.
  • Yee BE; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Mata J; School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Vijayan A; Australian Center for Nanomedicine, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Kumar N; School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Tilley RD; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Waters SA; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), University of New South Wales, Sydney, NSW, 2052, Australia.
  • Kilian KA; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
Nat Commun ; 14(1): 6604, 2023 10 23.
Article en En | MEDLINE | ID: mdl-37872151
ABSTRACT
Soft materials in nature are formed through reversible supramolecular assembly of biological polymers into dynamic hierarchical networks. Rational design has led to self-assembling peptides with structural similarities to natural materials. However, recreating the dynamic functional properties inherent to natural systems remains challenging. Here we report the discovery of a short peptide based on the tryptophan zipper (trpzip) motif, that shows multiscale hierarchical ordering that leads to emergent dynamic properties. Trpzip hydrogels are antimicrobial and self-healing, with tunable viscoelasticity and unique yield-stress properties that allow immediate harvest of embedded cells through a flick of the wrist. This characteristic makes Trpzip hydrogels amenable to syringe extrusion, which we demonstrate with examples of cell delivery and bioprinting. Trpzip hydrogels display innate bioactivity, allowing propagation of human intestinal organoids with apical-basal polarization. Considering these extensive attributes, we anticipate the Trpzip motif will prove a versatile building block for supramolecular assembly of soft materials for biotechnology and medicine.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triptófano / Hidrogeles Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triptófano / Hidrogeles Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article