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Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Schmidt, Henrik; Raj, Timsse; O'Neill, Thomas J; Muschaweckh, Andreas; Giesert, Florian; Negraschus, Arlinda; Hoefig, Kai P; Behrens, Gesine; Esser, Lena; Baumann, Christina; Feederle, Regina; Plaza-Sirvent, Carlos; Geerlof, Arie; Gewies, Andreas; Isay, Sophie E; Ruland, Jürgen; Schmitz, Ingo; Wurst, Wolfgang; Korn, Thomas; Krappmann, Daniel; Heissmeyer, Vigo.
Afiliación
  • Schmidt H; Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
  • Raj T; Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
  • O'Neill TJ; Research Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Muschaweckh A; Institute for Experimental Neuroimmunology, Technical University of Munich, School of Medicine, Munich 81675, Germany.
  • Giesert F; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Negraschus A; Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
  • Hoefig KP; Research Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 81337, Germany.
  • Behrens G; Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
  • Esser L; Institute for Immunology, Medical Faculty, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried 82152, Germany.
  • Baumann C; Research Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich 81337, Germany.
  • Feederle R; Monoclonal Antibody Core Facility, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Plaza-Sirvent C; Department of Molecular Immunology, ZKF2, Ruhr-University Bochum, Bochum 44801, Germany.
  • Geerlof A; Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Gewies A; Research Unit Signaling and Translation, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Isay SE; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich 81675, Germany.
  • Ruland J; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich 81675, Germany.
  • Schmitz I; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich 81675, Germany.
  • Wurst W; Department of Molecular Immunology, ZKF2, Ruhr-University Bochum, Bochum 44801, Germany.
  • Korn T; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
  • Krappmann D; Max-Planck-Institute of Psychiatry, Munich 80804, Germany.
  • Heissmeyer V; Chair of Developmental Genetics, TUM School of Life Sciences, Technische Universität München, Freising 85354, Germany.
Proc Natl Acad Sci U S A ; 120(48): e2309205120, 2023 Nov 28.
Article en En | MEDLINE | ID: mdl-37988467
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autoinmunidad / Encefalomielitis Autoinmune Experimental Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autoinmunidad / Encefalomielitis Autoinmune Experimental Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article