Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long-term opioid therapy and its deprescribing.

Manhapra, Ajay; MacLean, R Ross; Rosenheck, Robert; Becker, William C

Manhapra, Ajay; MacLean, R Ross; Rosenheck, Robert; Becker, William C.

Afiliación

Manhapra A; Section of Pain Medicine, Department of Physical Medicine & Rehabilitation Sciences, Hampton VA Medical Center, Hampton, Virginia, USA.
MacLean RR; New England Mental Illness Research Education and Clinical Center, West Haven, Connecticut, USA.
Rosenheck R; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Becker WC; Departments of Physical Medicine and Rehabilitation and Psychiatry, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Br J Clin Pharmacol ; 2023 Nov 22.

Article en En | MEDLINE | ID: mdl-37990580

Palabras clave

allostatic opponent effect; hyperkatefia; long-term opioid therapy; opioid induced hyperalgesia; opioid taper; pain relief; protracted withdrawal syndome

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2023 Tipo del documento: Article