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Formulation and evaluation of atovaquone-loaded macrophage-derived exosomes against Toxoplasma gondii: in vitro and in vivo assessment.
Goudarzi, Fatemeh; Jajarmi, Vahid; Shojaee, Saeedeh; Mohebali, Mehdi; Keshavarz, Hossein.
Afiliación
  • Goudarzi F; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
  • Jajarmi V; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
  • Shojaee S; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
  • Mohebali M; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
  • Keshavarz H; Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences , Tehran, Iran.
Microbiol Spectr ; 12(1): e0308023, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38014940
ABSTRACT
IMPORTANCE This study is the first of its kind that suggests exosomes as a nano-carrier loaded with atovaquone (ATQ), which could be considered as a new strategy for improving the effectiveness of ATQ against acute and chronic phases of Toxoplasma gondii.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Toxoplasma / Exosomas Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Toxoplasma / Exosomas Idioma: En Año: 2024 Tipo del documento: Article