Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling.
Trends Biochem Sci
; 49(4): 280-282, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38233283
ABSTRACT
Recent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by Yadav et al. has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complemento C5a
/
Anafilatoxinas
Idioma:
En
Año:
2024
Tipo del documento:
Article