A near-infrared fluorescent probe for detecting hydrazine metabolized from isoniazid in living cells.
Luminescence
; 39(1): e4676, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38286600
ABSTRACT
Isoniazid is a drug for treating tuberculosis, but hydrazine (N2 H4 ), the major metabolite of isoniazid, can cause hepatotoxicity. Therefore, monitoring the content of N2 H4 in time is of great significance for studying the hepatotoxicity induced by isoniazid. In this study, a near-infrared fluorescent probe (BC-N) was designed and synthesized based on the specific reaction of acetyl ester with N2 H4 . BC-N exhibits excellent selectivity, sensitivity, and biocompatibility. In addition, BC-N is applied in the visualization of N2 H4 produced from isoniazid in living cells and is a potential tool for monitoring hepatotoxicity induced by isoniazid.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Isoniazida
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article