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Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking.
Hennessy, Joseph; Klimkowski, Piotr; Singleton, Daniel; Gibney, Alex; Coche, Malou; Farrell, Nicholas P; El-Sagheer, Afaf H; Brown, Tom; Kellett, Andrew.
Afiliación
  • Hennessy J; SSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.
  • Klimkowski P; Chemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK.
  • Singleton D; ATDBio Ltd., School of Chemistry, University of Southampton Southampton SO17 1BJ UK.
  • Gibney A; SSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.
  • Coche M; SSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.
  • Farrell NP; Department of Chemistry, Virginia Commonwealth University Richmond VA 23284-2006 USA.
  • El-Sagheer AH; Chemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK.
  • Brown T; School of Chemistry, University of Southampton Southampton SO17 1BJ UK.
  • Kellett A; Department of Science and Mathematics, Faculty of Petroleum and Mining, Engineering, Suez University Suez 43721 Egypt.
RSC Med Chem ; 15(2): 485-491, 2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38389892
ABSTRACT
We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne-amine nucleobase monomer called AP-C3-dT that enables dual 'click' platinum(ii) drug conjugation and thiazole orange fluorophore coupling. Thiazole orange enhances the binding of Pt(ii)-TFO hybrids and provides an intrinsic method for monitoring triplex formation. These hybrid constructs possess increased stabilisation and crosslinking properties in comparison to earlier Pt(ii)-TFOs, and demonstrate sequence-specific binding at neutral pH.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article