Preparation and evaluation of transdermal permeation of Huperzine A ethosomes gel in vitro.
BMC Pharmacol Toxicol
; 25(1): 21, 2024 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-38409046
ABSTRACT
This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical properties were characterized. A comparison was made between Huperzine A ethosomes gel, ordinary gel, and cream. The Franz diffusion cell test on mouse abdominal skin was conducted, and Huperzine A concentration was determined using LC-MS/MS. Transdermal volume, skin retention, and transdermal rate were used to assess the percutaneous permeability of the three preparations. Results demonstrated that Huperzine A ethosomes gel exhibited significantly higher accumulative permeation, transdermal rate, and skin retention compared to ordinary gel and cream. The findings suggest that Huperzine A ethosomes gel, with its controllable quality and favorable transdermal absorption properties, holds potential as a safe option for clinical administration.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Piel
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Alcaloides
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Espectrometría de Masas en Tándem
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article