[Determination of perchlorate and chlorate in drinks by ultra-performance liquid chromatography-tandem mass spectrometry].
Wei Sheng Yan Jiu
; 53(1): 102-108, 2024 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-38443180
ABSTRACT
OBJECTIVE:
To establish a method for determination of perchlorate and chlorate in drinks by ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) based on isotopic internal standard method.METHODS:
The perchlorate and chlorate residue in liquid drinks were extracted with methanol, in solid drinks with acetic acid solution, then centrifuged. The supernatant was cleaned-up with PSA/C18 cleanup tube. The separation of perchlorate and chlorate was carried out on a Acquity CSH fluorophenyl column(100 mm×2.1mm, 1.7 µm) and the detection was performed with tandem mass spectrometry with internal standard method for quantification.RESULTS:
The peak area ratio of perchlorate and chlorate had a good linear relationship with their mass concentration within their respective linear ranges, with correlation coefficients(r) greater than 0.999. The limits of detection of perchlorate and chlorate were 0.2and 1 µg/L respectively and the limits of quantification were 0.5 and 3 µg/L respectively. The mean recoveries of two compounds were from 84.0% to 105.5% with relative standard deviations from 4.2% to 17.0% and 82.7% to 112.1% with relative standard deviations from 5.5% to 18.4%(n=6), respectively. The perchlorates in 11 kinds of beverage samples were 0.53-4.12 µg/L, chlorates were 3.27-61.86 µg/L.CONCLUSION:
This method is simple, sensitive, accurate and reliable, which is suitable for the determination of perchlorate and chlorate in drinks.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cloratos
/
Percloratos
Idioma:
Zh
Año:
2024
Tipo del documento:
Article