The evolutionary safety of mutagenic drugs should be assessed before drug approval.
PLoS Biol
; 22(3): e3002570, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38489394
ABSTRACT
Some drugs increase the mutation rate of their target pathogen, a potentially concerning mechanism as the pathogen might evolve faster toward an undesired phenotype. We suggest a four-step assessment of evolutionary safety for the approval of such treatments.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aprobación de Drogas
/
Mutágenos
Idioma:
En
Año:
2024
Tipo del documento:
Article