Clinical translation of pluripotent stem cell-based therapies: successes and challenges.
Development
; 151(7)2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-38564308
ABSTRACT
The translational stem cell research field has progressed immensely in the past decade. Development and refinement of differentiation protocols now allows the generation of a range of cell types, such as pancreatic ß-cells and dopaminergic neurons, from human pluripotent stem cells (hPSCs) in an efficient and good manufacturing practice-compliant fashion. This has led to the initiation of several clinical trials using hPSC-derived cells to replace lost or dysfunctional cells, demonstrating evidence of both safety and efficacy. Here, we highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in clinical translation of cell therapies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Pluripotentes
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article