DTKGIN: Predicting drug-target interactions based on knowledge graph and intent graph.
Methods
; 226: 21-27, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38608849
ABSTRACT
Knowledge graph intent graph attention mechanism Predicting drug-target interactions (DTIs) plays a crucial role in drug discovery and drug development. Considering the high cost and risk of biological experiments, developing computational approaches to explore the interactions between drugs and targets can effectively reduce the time and cost of drug development. Recently, many methods have made significant progress in predicting DTIs. However, existing approaches still suffer from the high sparsity of DTI datasets and the cold start problem. In this paper, we develop a new model to predict drug-target interactions via a knowledge graph and intent graph named DTKGIN. Our method can effectively capture biological environment information for targets and drugs by mining their associated relations in the knowledge graph and considering drug-target interactions at a fine-grained level in the intent graph. DTKGIN learns the representation of drugs and targets from the knowledge graph and the intent graph. Then the probabilities of interactions between drugs and targets are obtained through the inner product of the representation of drugs and targets. Experimental results show that our proposed method outperforms other state-of-the-art methods in 10-fold cross-validation, especially in cold-start experimental settings. Furthermore, the case studies demonstrate the effectiveness of DTKGIN in predicting potential drug-target interactions. The code is available on GitHub https//github.com/Royluoyi123/DTKGIN.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Descubrimiento de Drogas
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article