A hippocampus-accumbens code guides goal-directed appetitive behavior.
Nat Commun
; 15(1): 3196, 2024 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-38609363
ABSTRACT
The dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus accumbens (NAc) is a prominent projection target of dHPC and implicated in value-based action selection. Yet, the contents of the dHPCâNAc information stream and their acute role in behavior remain largely unknown. Here, we found that optogenetic stimulation of the dHPCâNAc pathway while mice navigated towards a learned reward location was both necessary and sufficient for spatial memory-related appetitive behaviors. To understand the task-relevant coding properties of individual NAc-projecting hippocampal neurons (dHPCâNAc), we used in vivo dual-color two-photon imaging. In contrast to other dHPC neurons, the dHPCâNAc subpopulation contained more place cells, with enriched spatial tuning properties. This subpopulation also showed enhanced coding of non-spatial task-relevant behaviors such as deceleration and appetitive licking. A generalized linear model revealed enhanced conjunctive coding in dHPCâNAc neurons which improved the identification of the reward zone. We propose that dHPC routes specific reward-related spatial and behavioral state information to guide NAc action selection.
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1
Banco de datos:
MEDLINE
Asunto principal:
Éteres Fosfolípidos
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Objetivos
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Hipocampo
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article