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Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
Many, Gina M; Sanford, James A; Sagendorf, Tyler J; Hou, Zhenxin; Nigro, Pasquale; Whytock, Katie L; Amar, David; Caputo, Tiziana; Gay, Nicole R; Gaul, David A; Hirshman, Michael F; Jimenez-Morales, David; Lindholm, Malene E; Muehlbauer, Michael J; Vamvini, Maria; Bergman, Bryan C; Fernández, Facundo M; Goodyear, Laurie J; Hevener, Andrea L; Ortlund, Eric A; Sparks, Lauren M; Xia, Ashley; Adkins, Joshua N; Bodine, Sue C; Newgard, Christopher B; Schenk, Simon.
Afiliación
  • Many GM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
  • Sanford JA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
  • Sagendorf TJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
  • Hou Z; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
  • Nigro P; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Whytock KL; Translational Research Institute, AdventHealth, Orlando, FL, USA.
  • Amar D; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Caputo T; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Gay NR; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Gaul DA; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
  • Hirshman MF; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Jimenez-Morales D; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Lindholm ME; Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
  • Muehlbauer MJ; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.
  • Vamvini M; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Bergman BC; Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Fernández FM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
  • Goodyear LJ; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Hevener AL; Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, USA.
  • Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
  • Sparks LM; Translational Research Institute, AdventHealth, Orlando, FL, USA.
  • Xia A; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Adkins JN; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Joshua.Adkins@pnnl.gov.
  • Bodine SC; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. bodines@omrf.org.
  • Newgard CB; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. bodines@omrf.org.
  • Schenk S; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.
Nat Metab ; 6(5): 963-979, 2024 May.
Article en En | MEDLINE | ID: mdl-38693320
ABSTRACT
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Caracteres Sexuales / Grasa Subcutánea / Tejido Adiposo Blanco Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Caracteres Sexuales / Grasa Subcutánea / Tejido Adiposo Blanco Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article