Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones.
J Am Chem Soc
; 146(19): 12895-12900, 2024 May 15.
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| ID: mdl-38696162
ABSTRACT
A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion.
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2024
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Article