MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.
Genet Test Mol Biomarkers
; 28(6): 263-266, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38717090
ABSTRACT
Background:
Several studies in mothers of infants with Down syndrome (DS) (MoIDS) have suggested that the 677C>T and 1298A>C variants of the 5,10-methylentetrahydrofolate reductase (MTHFR) gene can increase the risk of having a child with DS.Aim:
This study aimed to evaluate the MTHFR 677C>T and 1298A>C variants as potential maternal risk factors for DS. Materials andMethods:
Using TaqMan allelic discrimination assay, we genotyped 95 MoIDS and 164 control mothers from western Mexico. Data were analyzed using logistic regression analysis.Results:
We found that MoIDS had a significantly higher risk for the MTHFR 677TT genotype (adjusted odds ratio [aOR] = 3.4, 95% confidence interval [95% CI] 1.1-10.6), and the MTHFR 677T allele (aOR = 1.5, 95% CI 1.0-2.3), particularly in MoIDS <35 years of age.Conclusions:
Our findings indicate that the presence of the 677TT genotype and 677T allele of the MTHFR 677C>T variant are maternal risk factors for DS in Mexican MoIDS.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Down
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Metilenotetrahidrofolato Reductasa (NADPH2)
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Alelos
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Genotipo
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Madres
Límite:
Adult
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
País/Región como asunto:
Mexico
Idioma:
En
Año:
2024
Tipo del documento:
Article