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Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression Fractures.
Zhang, Songzi; Lee, Yunhwan; Liu, Yanting; Yu, Yerin; Han, Inbo.
Afiliación
  • Zhang S; Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
  • Lee Y; Department of Medicine, School of Medicine, CHA University, Seongnam-si 13496, Republic of Korea.
  • Liu Y; Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
  • Yu Y; Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
  • Han I; Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea.
Int J Mol Sci ; 25(9)2024 May 02.
Article en En | MEDLINE | ID: mdl-38732198
ABSTRACT
Osteoporotic vertebral compression fractures (OVCFs) significantly increase morbidity and mortality, presenting a formidable challenge in healthcare. Traditional interventions such as vertebroplasty and kyphoplasty, despite their widespread use, are limited in addressing the secondary effects of vertebral fractures in adjacent areas and do not facilitate bone regeneration. This review paper explores the emerging domain of regenerative therapies, spotlighting stem cell therapy's transformative potential in OVCF treatment. It thoroughly describes the therapeutic possibilities and mechanisms of action of mesenchymal stem cells against OVCFs, relying on recent clinical trials and preclinical studies for efficacy assessment. Our findings reveal that stem cell therapy, particularly in combination with scaffolding materials, holds substantial promise for bone regeneration, spinal stability improvement, and pain mitigation. This integration of stem cell-based methods with conventional treatments may herald a new era in OVCF management, potentially improving patient outcomes. This review advocates for accelerated research and collaborative efforts to translate laboratory breakthroughs into clinical practice, emphasizing the revolutionary impact of regenerative therapies on OVCF management. In summary, this paper positions stem cell therapy at the forefront of innovation for OVCF treatment, stressing the importance of ongoing research and cross-disciplinary collaboration to unlock its full clinical potential.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fracturas de la Columna Vertebral / Medicina Regenerativa / Fracturas por Compresión / Fracturas Osteoporóticas Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fracturas de la Columna Vertebral / Medicina Regenerativa / Fracturas por Compresión / Fracturas Osteoporóticas Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article