Posterior Segment Manifestations of Syphilis and Correlation With Serologic Markers of Infection.
Ophthalmic Surg Lasers Imaging Retina
; 55(9): 511-516, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38752914
ABSTRACT
BACKGROUND AND OBJECTIVE:
Retrospective analysis correlating serologic titers of ocular syphilis with posterior segment manifestations. PATIENTS ANDMETHODS:
This study consisted of 40 patients (80 eyes imaged, 68 affected) with positive rapid plasma reagin (RPR) and Treponema Pallidum immunoglobulin G. We collected demographic and presentation data including HIV status, absolute CD4 count, RPR, cerebrospinal fluid-venereal disease research laboratory (CSF-VDRL) test, and retinal zone. We categorized imaging into syphilitic outer retinopathy (SOR), acute syphilitic posterior placoid chorioretinopathy, retinitis/chorioretinitis (RC), and papillitis. Multivariate analysis correlated HIV status, RPR, and VDRL titers with posterior segment findings and zone.RESULTS:
Mean age of 42.8 ± 10.7 years, with 70% male patients. Presenting visual acuity (logMAR) 0.66 ± 0.74 did not correlate with RPR, nor was it associated with papillitis, RC, or acute syphilitic posterior placoid chorioretinopathy. Higher RPR (≥ 1128) positively associated with SOR (P = 0.031) and zone 1 (odds ratio [OR], 1.62; P = 0.02), but negatively associated with zone 2 (OR 0.35; P = 0.005). HIV positivity increased RC odds (OR, 4.45; P = 0.047).CONCLUSION:
Higher RPR correlated with SOR and zone 1, whereas HIV positivity correlated with RC. [Ophthalmic Surg Lasers Imaging Retina 2024;55511-516.].
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Treponema pallidum
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Serodiagnóstico de la Sífilis
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Sífilis
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Agudeza Visual
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Infecciones Bacterianas del Ojo
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2024
Tipo del documento:
Article