Prognostic implications of unbiased molecular categorization in kidney disease.
Kidney Int
; 105(6): 1162-1164, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38777400
ABSTRACT
In this commentary, a novel approach to the reclassification of chronic kidney disease is reviewed. In the revisited study, the investigators identify 4 distinct subtypes of kidney disease derived from an unbiased self-organizing map of transcriptomic data from kidney biopsy samples. These molecular subtypes then are characterized by biologic cell processes, clinical and histopathologic features, urinary proteomics, and disease progression. The strengths and limitations of the self-organizing map approach are assessed; the prognostic, diagnostic, and therapeutic implications are considered briefly.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Progresión de la Enfermedad
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Proteómica
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Insuficiencia Renal Crónica
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Transcriptoma
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Riñón
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article