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Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood-brain barrier.
Wang, Yinying; Chen, Rongsha; Shi, Guolin; Huang, Xinwei; Li, Ke; Wang, Ruohua; Cao, Xia; Yang, Zhongshan; Zhao, Ninghui; Yan, Jinyuan.
Afiliación
  • Wang Y; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Chen R; Yunnan Provincial Key Laboratory of Molecular Biology for Sino Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China.
  • Shi G; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Huang X; Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Li K; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Wang R; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Cao X; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Yang Z; Central Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
  • Zhao N; Yunnan Provincial Key Laboratory of Molecular Biology for Sino Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China.
  • Yan J; Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
Neural Regen Res ; 2024 Jun 26.
Article en En | MEDLINE | ID: mdl-38934394
ABSTRACT
ABSTRACT Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse model of Parkinson's disease and found that it effectively reduced dopamine neuron injury, neurotransmitter dopamine release, and motor symptoms. These neuroprotective effects of chitosan were related to bacterial metabolites, specifically short-chain fatty acids, and chitosan administration altered intestinal microbial diversity and decreased short-chain fatty acid production in the gut. Furthermore, chitosan effectively reduced damage to the intestinal barrier and the blood-brain barrier. Finally, we demonstrated that chitosan improved intestinal barrier function and alleviated inflammation in both the peripheral nervous system and the central nervous system by reducing acetate levels. Based on these findings, we suggest a molecular mechanism by which chitosan decreases inflammation through reducing acetate levels and repairing the intestinal and blood-brain barriers, thereby alleviating symptoms of Parkinson's disease.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2024 Tipo del documento: Article