Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Science
; 221(4608): 368-70, 1983 Jul 22.
Article
en En
| MEDLINE
| ID: mdl-6408733
ABSTRACT
Depletion of polyamines in 9L rat brain tumor cells by treatment with alpha-difluoromethylornithine dramatically altered DNA conformation as measured by viscoelastometry. The reduction of intracellular putrescine and spermidine concentrations to less than 5 percent of their concentrations in control cells decreased the sensitivity of 9L cell DNA to x-irradiation and increased the maximum viscoelastic retardation time of the DNA. Both of these phenomena were reversed by addition of exogenous putrescine.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Poliaminas
/
Neoplasias Encefálicas
/
ADN de Neoplasias
Límite:
Animals
Idioma:
En
Año:
1983
Tipo del documento:
Article