Synthesis and biological activities of 4"-deoxy-4"-sulfonamido-oleandomycin derivatives.
Antimicrob Agents Chemother
; 25(1): 113-7, 1984 Jan.
Article
en En
| MEDLINE
| ID: mdl-6703674
ABSTRACT
Chemical modification of the macrolide antibiotic oleandomycin (C-1) is described. Reductive amination of 11-acetyl-4"-deoxy-4"-oxo-oleandomycin (C-6) with ammonium acetate provides amino-oleandomycin derivative C-7 in which the 4"-amine is oriented in the axial configuration. The structure-activity relationship of a series of 4"-sulfonamide analogs prepared from amino-oleandomycin derivative C-7 is discussed. Noteworthy is the significant in vitro potency enhancement of the para-chlorobenzenesulfonamide analog C-12 over that of the parent oleandomycin. The absolute configuration of the 4"-amino-oleandomycin derivative C-7 was established through X-ray analysis of the para-iodobenzenesulfonamide analog C-14.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Oleandomicina
Límite:
Animals
Idioma:
En
Año:
1984
Tipo del documento:
Article