A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension.
J Int Med Res
; 10(2): 82-6, 1982.
Article
en En
| MEDLINE
| ID: mdl-6802690
ABSTRACT
A fixed combination of metoprolol slow-release 200 mg and chlorthalidone 25 mg was given once daily over a 3 months period in forty out-patients with mild-to-moderate arterial hypertension stage I or II WHO. The combination elicited a clear-cut antihypertensive effect lasting at least 24 hours after drug. As compared with pre-treatment values, systolic and diastolic blood pressures were gradually reduced within the first month of treatment, remaining nearly constant in the following 2 months. Treatment was well tolerated by all patients. Neither serum potassium nor any other laboratory test (creative, glucose, uric acid, etc) showed significant changes. In conclusion, slow-release metoprolol fixed association with chlorthalidone provides a safe and effective treatment of arterial hypertension even on a long-term basis. The once daily dosing schedule may considerably improve patient's compliance.
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Banco de datos:
MEDLINE
Asunto principal:
Propanolaminas
/
Clortalidona
/
Hipertensión
/
Metoprolol
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Año:
1982
Tipo del documento:
Article