Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat.
J Natl Cancer Inst
; 65(6): 1299-301, 1980 Dec.
Article
en En
| MEDLINE
| ID: mdl-6933274
ABSTRACT
The effect of supplemental dietary selenium on the postinitiation state of N-methyl-N-nitrosourea (MNU)-induced mammary carcinogenesis was investigated in noninbred female Sprague-Dawley rats. Mammary cancer was induced by a single iv injection of MNU. Supplemental selenium feeding was begun 7 days after carcinogen treatment. Feeding of selenium prolonged the latency of mammary cancer appearance and resulted in a reduction in the average number of cancers per rat. The results suggested an inhibitory effect of pharmacologic levels of dietary selenium on the postinitiation stage of mammary carcinogenesis.
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Banco de datos:
MEDLINE
Asunto principal:
Selenio
/
Neoplasias Mamarias Experimentales
/
Metilnitrosourea
/
Compuestos de Nitrosourea
Límite:
Animals
Idioma:
En
Año:
1980
Tipo del documento:
Article