Toxicity evaluation of water soluble substances of dental materials by means of cell population in vitro.

ABSTRACT

The paper describes a method of evaluation of the biocompatibility of dental restorative materials with a monolayer cell culture system. Semisolid and solid materials were eluted under physiological conditions. The cell monolayer was exposed to the eluates. The method enables the recognition of toxic ingredients and thus their elimination by the producer of these materials as well as the comparison of the cytotoxicity of newly developed materials with conventional ones.