Follicular lymphoma adjacent to foreign body granulomatous inflammation and fibrosis surrounding silicone breast prosthesis.
Am J Surg Pathol
; 19(6): 712-7, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7755157
ABSTRACT
Silicone lymphadenopathy has been associated with fracture and/or erosive breakdown of silastic implants in joint replacements and is also known to occur with cosmetic and reconstructive breast implant surgery. In the orthopedic literature rare malignant lymphomas have been reported in association with silicone granulomas in lymph nodes; whether silicone is a causative agent remains controversial. We report a single case of a 56-year-old woman who had painful capsular contractures and a 2-cm palpable nodule medial to her silicone mammary implant. Histologically the mass comprised an extra nodal follicular mixed lymphoma with surrounding granulomatous response to polarizable foreign body material. Paraffin immunophenotyping, bcl-2 protein staining, and gene rearrangement analysis verified this diagnosis.
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Banco de datos:
MEDLINE
Asunto principal:
Siliconas
/
Neoplasias de la Mama
/
Reacción a Cuerpo Extraño
/
Linfoma Folicular
/
Implantes de Mama
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
1995
Tipo del documento:
Article