Structure-activity relationships within a series of C(7)-substitutedoxyiminocephalosporins containing the C(3)-methylaminopyridiniumthiomethyl substituent. Synthesis and biological properties of BRL 57342 and some close analogues.
J Antibiot (Tokyo)
; 48(5): 417-24, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-7797444
ABSTRACT
(6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-[(S)-carboxy(3,4- dihydroxyphenyl)methyl]oxyimino]acetamido]-3-(1-methylaminopyri dinium-4-thiomethyl)ceph-3-em-4-carboxylate sodium salt (BRL 57342, 1f) combines excellent in vitro antibacterial potency against Gram-positive and Gram-negative bacteria, including P. aeruginosa and Acinetobacter spp., with excellent stability to extended spectrum beta-lactamases. This potency is reflected in in vivo efficacy studies.
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Banco de datos:
MEDLINE
Asunto principal:
Cefalosporinas
Límite:
Animals
/
Humans
Idioma:
En
Año:
1995
Tipo del documento:
Article