[Role of cardiac renin-angiotensin system in swimming induced physiological myocardial hypertrophy].
Sheng Li Xue Bao
; 46(5): 509-13, 1994 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-7846553
ABSTRACT
To determine the contribution of cardiac renin-angiotensin system (RAS) to the physiological myocardial hypertrophy induced by swimming training and the relationship between locally produced and circulating RAS, both ventricular and plasma angiotensin (Ang) I and II contents, ventricular angiotensin converting enzyme (ACE) and plasma renin activity (PRA) were detected by means of radioimmunoassay and biochemical method. It was shown that after 5 weeks of swimming, the ventricular wet weight to body weight ratio (V/Bwt) and Ang II in both left and right ventricles and ACE activity increased markedly as compared with the controls (P < 0.05). Furthermore, significantly positive correlation was found between the ventricular Ang II and V/Bwt (r = 0.7721, P < 0.001), while the plasma Ang I and II and PRA remained at the control level. No correlation was found between plasma Ang II and V/Bwt. These above findings suggest that cardiac RAS may play an important role in physiological myocardial hypertrophy and to a large extent is in dependent on circulating RAS.
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Banco de datos:
MEDLINE
Asunto principal:
Sistema Renina-Angiotensina
/
Cardiomegalia
/
Esfuerzo Físico
Límite:
Animals
Idioma:
Zh
Año:
1994
Tipo del documento:
Article