The mitogen-induced generation of interferon-gamma producing cells in cultures of rhesus monkey peripheral blood mononuclear cells is age-dependent.
J Med Primatol
; 23(1): 42-8, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-7932638
ABSTRACT
An enzyme-linked immunoabsorbent spot (ELISPOT) assay has been developed for measuring the frequency of interferon-gamma (IFN-gamma) producing cells in rhesus monkeys. Aged monkeys revealed, upon mitogenic stimulation, a significantly higher percentage of IFN-gamma secreting peripheral blood mononuclear cells (PBMC) compared to young animals. No correlation was found between the frequency of IFN-gamma producing PBMC and the mitogen-driven proliferation, indicating that in rhesus monkeys no direct correlation exists between these two activation parameters.
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Banco de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Interferón gamma
/
Macaca mulatta
Límite:
Animals
Idioma:
En
Año:
1994
Tipo del documento:
Article