Exocytosis in spermatozoa in response to progesterone and zona pellucida.
Science
; 266(5190): 1578-81, 1994 Dec 02.
Article
en En
| MEDLINE
| ID: mdl-7985030
ABSTRACT
Exocytosis in mammalian spermatozoa (the acrosome reaction) is a process essential for fertilization. Both progesterone and zona pellucida induce exocytosis in spermatozoa, which may encounter both during penetration of the oocyte's vestments. When mouse spermatozoa were exposed first to progesterone and then to zona pellucida, exocytosis was enhanced to a greater degree than that seen when the agonists were presented together or in the inverse order, which suggests that the steroid exerts a priming effect. Progesterone similarly primed the generation of intracellular messengers evoked by zona pellucida. The effects triggered by progesterone were mimicked by gamma-aminobutyric acid (GABA) and were blocked by bicuculline, which indicates that the steroid acts on a GABAA receptor.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Progesterona
/
Espermatozoides
/
Zona Pelúcida
/
Acrosoma
/
Exocitosis
Límite:
Animals
Idioma:
En
Año:
1994
Tipo del documento:
Article