Transcription-modulatory activity of full-length E6 and E6*I proteins of human papillomavirus type 16.
Virology
; 203(1): 36-42, 1994 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-8030282
ABSTRACT
The E6 gene of human papillomavirus type 16 (HPV16) has the potential to encode full-length as well as truncated E6 proteins (E6*I and E6*II) by alternative splicings. Spliced ORF E6*I is considered to facilitate the translation of the neighboring E7 ORF; however, the putative E6*I protein is suspected to be functionless. In this study, the transcription-modulatory functions of full-length E6 and E6*I proteins were examined using cDNAs from a cervical carcinoma cell line. E6*I cDNA was able to trans-activate the autologous P97 promoter and the heterologous adenovirus E2 promoter. Full-length E6 was found to trans-activate the heterologous promoter, but repress transcription from the autologous P97 promoter. The transcription-modulatory functions of full-length E6 and E6*I proteins suggested that transcriptional regulation of HPVs associated with mucosal malignant lesions is complex.
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Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Transcripción Genética
/
Regulación Viral de la Expresión Génica
/
Proteínas Oncogénicas Virales
Límite:
Animals
/
Humans
Idioma:
En
Año:
1994
Tipo del documento:
Article