[Concentrations of propofol in maternal and fetal blood during anesthesia for cesarean section]. / Concentrazioni di propofol nel sangue materno e fetale in corso di anestesia per taglio cesareo.
Minerva Anestesiol
; 59(9): 435-40, 1993 Sep.
Article
en It
| MEDLINE
| ID: mdl-8278065
ABSTRACT
The authors studied, until the delivery, the pharmacokinetics of propofol during cesarean section. Ten patients were studied. Anaesthesia was induced and maintained with propofol (2 mg/kg in 15 seconds; 3 mg/kg/h until the end of the operation). All the patients have been intubated after the administration of atracurium 0.4 mg/kg and artificially ventilated with O2/N2O (FiO2 0.4). A series of maternal blood samples was obtained. Umbilical artery and venous blood samples have been obtained at delivery. Propofol levels in whole blood samples have been measured by a HPLC method (High pressure liquid chromatography). The results were at delivery the mean ratio of the drug concentration in the umbilical vein to that in maternal vein was 0.53 +/- 0.16 micrograms/ml; the mean concentration in the umbilical vein was 0.96 +/- 0.31 micrograms/ml. The anaesthesiological protocol was clinically satisfactory and had no adverse effects on mother and foetus.
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Banco de datos:
MEDLINE
Asunto principal:
Embarazo
/
Propofol
/
Cesárea
/
Sangre Fetal
/
Anestesia Obstétrica
Tipo de estudio:
Guideline
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
It
Año:
1993
Tipo del documento:
Article