Comparative perilymph permeability of cephalosporins and its significance in the treatment and prevention of suppurative labyrinthitis.
Ann Otol Rhinol Laryngol
; 105(1): 54-7, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8546425
ABSTRACT
Cephalosporins are nonototoxic antibiotics that provide excellent coverage for almost all bacteria that can cause suppurative labyrinthitis. In this study we performed comparative perilymph permeability determinations of the three cephalosporins that we deemed to have the most clinical potential in these varied situations. Perilymph pharmacokinetic profiles were established for ceftazidime, cefuroxime, and cefotaxime and its metabolite desacetylcefotaxime in 36 guinea pigs by using the technique of high-performance liquid chromatography. At 1, 2, 3, 4, and 6 hours after intravenous administration of the three cephalosporins at a dose of 100 mg/kg of body weight, ceftazidime consistently exhibited the highest perilymph concentration. Desacetylcefotaxime showed the next highest capacity for penetration into perilymph. Keeping in mind that the choice of drug for the treatment of suppurative labyrinthitis should be based foremost on culture and sensitivity studies, we consider ceftazidime to be the first-line agent for treatment and prevention of both meningogenic labyrinthitis and labyrinthitis complicating acute or chronic otitis media.
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Banco de datos:
MEDLINE
Asunto principal:
Perilinfa
/
Cefalosporinas
/
Laberintitis
Límite:
Animals
Idioma:
En
Año:
1996
Tipo del documento:
Article