Suppression of platelet-derived growth factor alpha- and beta-receptor mRNA levels in human fibroblasts by SV40 T/t antigen.
J Cell Physiol
; 166(1): 12-21, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8557760
ABSTRACT
It is known that down-regulation of cell surface platelet-derived growth factor (PDGF) receptors accompanies transformation by SV40. In this work human embryonic lung fibroblasts were used as a model system to study the effects of SV 40 on PDGF receptor expression. It is shown that transformation by SV 40 early region leads to a total loss of PDGF alpha-receptor and partial loss of beta-receptor mRNA. Microinjection experiments revealed that receptor down-regulation was a primary effect, and not only secondary to transformation and clonal selection. Total loss of PDGF alpha-receptor expression requires both large T and small t, and down-regulation of the PDGF alpha-receptor occurs independently of p53 and Rb binding to large T.
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Banco de datos:
MEDLINE
Asunto principal:
Antígenos Transformadores de Poliomavirus
/
Receptores del Factor de Crecimiento Derivado de Plaquetas
/
Poliomavirus
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
1996
Tipo del documento:
Article